The actor will next be seen in the ensemble comedy Housefull 2.
He told DNA India: "I am fed up of the fact that every film that works has a sequel in the offing. Like they asked me, 'Tere Naal Love Ho Gaya is a success so let's do a sequel to it'.
"When you do sequels, you are almost repeating the same genre, characters, same style of filmmaking all this happens in slightly bigger but in the same space.
"So every year if I do sequels then there is nothing new that I am doing. As an actor, I would love to do something else also. I had signed three sequels last year - Dhamaal, Housefull, Kya Kool Hai Hum. But this time I have signed only one sequel, Masti, and one thriller and some other films."
In February, the newly-married Deshmukh revealed that he has never seen himself as a "bachelor".
The actor married long-term girlfriend Genelia D'Souza this year shortly after the release of their film together Tere Naal Love Ho Gaya.