The actor will be starring opposite Neha Sharma and Sarah Jane Dias in the film.
He told IANS: "It doesn't feel like we are working with newcomers. Their energy, enthusiasm, freshness has made our film look fresh with a new energy.
"They are far more confident. When I did my second film, I was not as confident as them. I wish I was as confident as these two are."
Dias first starred in 2011's Game, while Sharma made her debut in Crook: It's Good to be Bad.
It was reported in May that the actor had saved former Miss India Dias from a mob of fans at the airport.
Deshmukh has said that he plans never to star in a sequel again after Kyaa Super Kool Hain Hum's release.
Watch the trailer for Kyaa Super Kool Hain Hum below: