Following on the heals of the release of Fear Itself #4, the image promises an all-out brawl in next month's issue.
The teaser shows close-ups of Thor, the Hulk and the Thing - the latter two having fallen under the power of the Serpent and transformed into his hammer-wielding 'Worthy'.
A second teaser hints at the ongoing events in Fear Itself: The Deep #2, Uncanny X-Men #540 and Invincible Iron Man #506.
Another recent teaser for the Uncanny X-Men tie-in arc has shown Colossus transformed into a version of the Juggernaut.
Matt Fraction and Stuart Immonen's core miniseries sees Marvel's heroes facing off against the God of Fear, an ancient enemy of Odin who has escaped his prison at the bottom of the sea.
The event has already resulted in the death of Bucky Barnes.
Fear Itself #5 will be released on August 10.