The publisher has hinted that the crossover event will introduce some major continuity changes, giving rise to speculation that several titles could be overhauled.
Alonso has now stamped out rumours of a full reboot, describing the series as the "first chapter for the next decade's worth of stories".
He told Newsarama: "The Marvel Universe is changed by AvX. It is not a reboot or a retcon. It is the Marvel Universe that you grew up in.
"But this story in many ways sort of serves as an endcap to a decade's worth of stories that we've been telling, and I think it begins a great first chapter for the next decade's worth of stories we're going to tell.
"I'm very excited about what we're doing. We had a fantastic summit. Some long-running creative shifts are occurring - you've heard about Brian [Michael Bendis], for instance; there may be others. We're very excited about where we're headed."
Avengers vs X-Men, which debuted last month, sees its fourth issue arrive in stores today (May 16).