The images, which show Marvel's heroes defeated, will be explained at San Diego Comic-Con International's Amazing Spider-Man panel, the publisher has promised.
The first shows Thor's hammer Mjolnir lying shattered on the ground.
A second teaser shows Wolverine's hand wreathed in flames.
Nothing else has been revealed regarding the project.
Amazing Spider-Man recently concluded the 'Ends of the Earth' storyline, which featured the Sinister Six and marked Peter Parker's 50th anniversary.
The Amazing Spider-Man panel will be held on July 15 at 12.30pm at Comic-Con.