Richard Corben will helm the horror title for Dark Horse Comics as part of an ongoing collaboration between the scribe and the publisher.
Corben is to adapt other tales from Poe's back catalogue for the Eisner-nominated anthology Dark Horse Presents, which was revived in April last year.
The Conqueror Worm depicts a betrayed man who hunts down his wife and her lover only to be subjected by a gruesome puppet show based on his life.
Corben previously tackled the work of Poe with the Haunt of Horror miniseries, a 2006 title from Marvel Comics inspired by classic horror.
Edgar Allan Poe's The Conqueror Worm is on sale November 21.