Creators, retailers and journalists have offered their reactions to the attack that has left 12 people dead and 58 injured.
Writer Brad Meltzer has countered suggestions that comics are to blame for the killings, saying that "anyone who says that to me is a little bit insane", according to Metromix.
"We can't possibly say this could be more tragic, but I do think that there's some twisted irony in the fact that it's a movie of someone who so many people look up to and a movie that celebrates someone who can stop this kind of violence," he continued.
DC Comics co-publisher Jim Lee tweeted his condolences. "Just shocked and saddened today - my thoughts and prayers go out to the victims' families and friends and everyone affected by this terrible tragedy," he wrote.
Gerry Gladston, co-owner and chairman of marketing at New York City's Midtown Comics, said: "I would worry a lot more about gun control than influence by comics and other pop culture and media.
"I think it's a senseless tragedy conducted by a psycho who took advantage of the mass popularity of this public event. He clearly wanted to make a big splash and he picked the biggest public spectacle he could find, and this week it happens to be The Dark Knight Rises."
"Life imitates art an awful lot in our world, and sometimes we can draw comparisons to things that are very tragic," says Jonah Weiland of Comic Book Resources.
"Anybody drawing assumptions between the actions of this man and things they've read in a comic book or a movie is just plain wrong.
"If you really look at who Batman is and what he stands for, he doesn't stand for what this guy did."
Batman and Robin artist Cameron Stewart tweeted: "Jesus, what an awful thing in Colorado. Sad and sickening.
"Media referring to it as 'Batman shooting' or 'Dark Knight Massacre' (which I think is needlessly sensational)."
Warner Bros has cancelled premieres in Paris, Japan and Mexico following the attack.
Anne Hathaway, who plays Selina Kyle/Catwoman in the film, has said that "my heart aches and breaks for the lives taken and altered by this unfathomably senseless act".
Police are currently investigating the apartment of shooting suspect James Holmes.