Following on from the events of Halo 3, it will once again feature Master Chief as lead character and will be released during the holiday season, 2012.
Halo 4 was officially unveiled at the end of Microsoft's E3 press conference in Los Angeles.
A remake of Halo: Combat Evolved was also confirmed, which will be released later this year to mark the ten-year anniversary of the original release.
Halo 4 was outed earlier today after a leaked report revealed that it would be on show during Microsoft's press event.
Fable: The Journey and a new Dance Central title were also outed and subsequently confirmed by Microsoft during its briefing.
More coverage from Microsoft's E3 2011 conference:
> Fable: The Journey announced for Kinect
> New Kinect Sports, Dance Central revealed
> Halo: Combat Evolved remake confirmed
> YouTube and live TV coming to Xbox 360
> Mass Effect 3 to feature Kinect support
> E3 2011: Microsoft conference live blog
View Halo 4's first screenshot and trailer below: