The extended E3 video will air at half-time on ITV at approximately 5.45pm.
The trailer offers a glimpse of the game's storyline, showing Master Chief on the planet Requiem.
Halo 4 is set four years after the events of its predecessor and marks the return of iconic hero Master Chief, representing the beginning of a brand new saga.
Halo 3 wrapped up the original trilogy in 2007, but the fate of Master Chief and his artificial intelligence companion Cortana was left open-ended.
Halo 4 will release exclusively on Xbox 360 on November 6 worldwide.
> 'Halo 4' multiplayer preview: WarGames is the fastest online Halo yet
> Read our 'Halo 4' interview on multiplayer and narrative
Watch the Halo 4 E3 trailer below: