Nintendo's Scott Moffitt said that the Wii U Gamepad could enhance the gameplay experience for Call of Duty, removing clutter from the screen.
"Do we want to reach out to the core audience? Absolutely," Moffitt told GameSpot.
"They're very much part of our audience and the group of consumers we hope will find the way you can re-imagine games on the Wii U.
"The Wii U could become the preferred way to play those games for some of the core gamers.
"You can imagine how a game like Call of Duty would work on the Wii U - the GamePad will allow you to declutter the TV and pull gaming items like maps down and not interrupt your interaction and enjoy the cinematic quality of the game on the TV.
"That's one application that could be exciting and could enhance gameplay for a core gamer."
Leaked scans from the latest issue of Nintendo Gamer list Black Ops 2 for a November release on Nintendo's new platform.
Neither Nintendo or Activision has confirmed the release, although Activision has promised to support the Wii U, with announcements expected soon.
Announced last month, Black Ops 2 is set during a 21st century Cold War and will release on November 13 on Xbox 360, PS3 and PC.
> Read our Call of Duty: Black Ops review
Photo gallery - first images of Black Ops 2: