It is once again followed by London 2012: The Game in second and The Amazing Spider-Man in third, while Dead Island: Game of the Year Edition climbs to fourth.
Spec Ops: The Line drops five places down to nine, above top ten re-entry Mario & Sonic at the London 2012 Olympic Games.
Following Mind Candy's success at last week's Develop Awards, Moshi Monsters: Moshling Zoo also rejoins the top 20 at 19, above fellow re-entry Skylanders Spyro's Adventure.
Namco Bandai's gravity-based shooter Inversion, meanwhile, makes its debut outside of the top 40, charting at 50 in its first week on sale.
The top ten in full:
1. (1) LEGO Batman 2: DC Super Heroes (Warner Bros. Interactive)
2. (2) London 2012: The Game (Sega)
3. (3) The Amazing Spider-Man (Activision)
4. (5) Dead Island: Game of the Year Edition (Koch Media)
5. (9) Ghost Recon: Future Soldier (Ubisoft)
6. (8) Modern Warfare 3 (Activision)
7. (6) Elder Scrolls V: Skyrim (Bethesda Softworks)
8. (7) FIFA 12 (Electronic Arts)
9. (4) Spec Ops: The Line (2K Games)
10. (11) Mario & Sonic at the London 2012 Olympic Games (Sega)
11. (14) Batman: Arkham City (Warner Bros. Interactive)
12. (13) Max Payne 3 (Rockstar)
13. (10) FIFA Street (Electronic Arts)
14. (12) Sniper Elite V2 (505 Games)
15. (16) Call Of Duty: Black Ops (Activision)
16. (18) Assassin's Creed Revelations (Ubisoft)
17. (23) LEGO Pirates of the Caribbean (Warner Bros.Interactive)
18. (15) Battlefield 3 (Electronic Arts)
19. (22) Moshi Monsters: Moshling Zoo (Mind Candy)
20. (25) Skylanders Spyro's Adventure (Activision)
Leisure software charts compiled by Chart Track, (C) 2012 UKIE Ltd.
Watch a trailer for LEGO Batman 2: DC Super Heroes below: