More than 40% of readers voted Mario Kart as the best game to play with family and friends.
Nintendo's kart-based racing game won in a landslide victory, in a poll dominated by Nintendo releases.
The only other games to receive close to 10% of votes or more were N64 title Goldeneye - which has since been remade - and the Smash Bros. franchise, suggesting that no-one does multiplayer quite like Nintendo.
FIFA and Bomberman were the next highest scorers, closely followed by the likes of Tekken, Micro Machines and Worms.
The original Mario Kart made its debut for the SNES in the early '90s. The franchise has appeared on Nintendo home consoles and handhelds ever since, and has even spawned a couple of arcade games.
Mario Kart 7 was voted the best game of 2011 in Digital Spy's end of year reader poll.
The game was also the fastest-selling Mario Kart title in history, and one of the first Nintendo 3DS games to sell more than one million copies in the US.
> Read our review of Mario Kart 7
Screenshot gallery - view Mario Kart 7 images below: