The new lineup means that long-running DJs Judge Jules and Gilles Peterson will present their final shows on the station in early 2012. Kissy Sell Out and Fabio & Grooverider will also be leaving the station.
Skream & Benga, Toddla T, Charlie Sloth and Friction will be presenting brand new shows on the network.
Friction - not to be confused with DJ Bobby Friction - will present a drum and bass show on Mondays at 2-4am, while Charlie Sloth will present his own show on Tuesdays at the same time.
Dubstep duo Skream & Benga will present a new dance music-themed show on Friday nights at 11pm-1am, with Toddla T arriving on air on Friday mornings at 2-4am.
Meanwhile, Annie Nightingale will move from Fridays to Saturdays at 3-5am, Mike Davies moves to Wednesdays at midnight-2am and Nihal moves from Wednesdays at midnight to 2-4am.
The changes are the first from new Radio 1 controller Ben Cooper, who took over from Andy Parfitt in October.
"We'd like to thank Jules, Gilles and Fabio & Grooverider for over a decade of hard work and commitment to music at Radio 1, and also to Kissy Sell Out for his contribution over the last three years. All are incredibly talented and we wish them the very best for the future."
Judge Jules revealed that he aims to return to his law roots, saying: "I've had an incredible time over the last 14 years at Radio 1. I'm going to continue DJ'ing and I'm having a bit of a career change - I'm off to become an Entertainment Lawyer at Sheridans."
Gilles Peterson - who is reportedly in talks with BBC 6 Music - added: "I've had an amazing 13 years at Radio 1 - to be able to get away with the radical music that I've pushed out has always surprised me and I thank Radio 1 for giving me the freedom to do that. I'm looking forward to continuing my work in the BBC family some time in the future."
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