Since graduating from TV's 21 Jump Street, Depp has firmly cemented himself as one of Hollywood's top A-list stars thanks to his eclectic career choices and mesmerising performances.
Digital Spy takes a look at five essential Johnny Depp film roles...
Edward Scissorhands (Edward Scissorhands, 1990)
Fresh from huge success with Batman, Tim Burton turned his attention to gothic fairytale Edward Scissorhands and cast Depp in the eponymous role. Through tight black leather, heavy make-up and with scissors for hands, Depp managed to convey a soulful performance as Vincent Price's human-like creation. Edward Scissorhands also started the long-running creative partnership between Depp and director Burton.
Gilbert Grape (What's Eating Gilbert Grape, 1993)
Leonardo DiCaprio may have bagged a 'Best Supporting Actor' Oscar nomination, but Depp is the solid emotional core for Lasse Hallström's moving drama. Depp's Gilbert finds it a struggle to cope with his mentally challenged brother Arnie (DiCaprio) and overweight mother Bonnie, who's sunk into depression after her husband's suicide. Depp isn't showy in the part, but his grounded turn is vital in making the dynamics of Gilbert Grape work.
Raoul Duke (Fear and Loathing in Las Vegas, 1998)
Depp underwent a physical transformation for Terry Gilliam's Fear and Loathing in Las Vegas, losing his hair for a live wire turn as Raoul Duke, the alias for Hunter S Thompson's gonzo writer. Depp, Gilliam and Thompson certainly made for a tantalising oddball triumvirate. Intriguingly, Depp had initially wanted Withnail & I's Bruce Robinson to make Fear and Loathing, but the director declined and it would be more than a decade before the pair hooked up on The Rum Diary.
George Jung (Blow, 2001)
After spending time sharing the screen with major movie stars such as Marlon Brando (Don Juan DeMarco, The Brave) and Al Pacino (Donnie Brasco), Depp took on the role of Blow's drug kingpin George Jung with gusto. Based on a true story, Blow sees Depp team up with Pablo Escobar (Cliff Curtis) to kick-start the cocaine trade in the '70s. Like Goodfellas before it, Blow is a cracking rise-and-fall tale that shows the personal turmoil created by a life of crime.
Captain Jack Sparrow (Pirates of the Caribbean, 2003-2011)
Remarkably, Depp's first Oscar nomination came not from his myriad of great performances in the '90s, but when he played Jack Sparrow for the first time in Pirates of the Caribbean: The Curse of the Black Pearl. Disney initially hated Depp's Keith Richards-inspired performance and wanted him subtitled, yet eight years and many box office dollars later Sparrow is one of Hollywood's most iconic modern heroes. Pirates has also given Depp the freedom to make any movie he desires.
Which Johnny Depp role is your favourite? Should Ed Wood, Benny & Joon and Finding Neverland be on this list? Leave your comments below!