He will play a past version of Colin Farrell's Doug Quaid character.
"Not to give away too much, but one of the big differences between the earlier film and this film is that not only do they erase his memory, but they change the way he looks, so he has a different face," producer Toby Jaffe told Screen Rant.
"Ethan plays who he was before they wiped his mind and changed his face."
Len Wiseman's forthcoming remake will also star Kate Beckinsale, Jessica Biel, Bryan Cranston and Bill Nighy.
The famous three-breasted prostitute from the original 1990, Arnold Schwarzenegger-starring film has been confirmed to make a reappearance.
Total Recall will arrive in US cinemas on August 3 and in the UK on August 22.
Watch the trailer for the Total Recall remake below: