The director discussed the challenges of moving from indie features like 500 Days of Summer to a special effects-packed action blockbuster.
> 'The Amazing Spider-Man' review: Digital Spy's verdict
"I was pretty cautious of trying to keep the pace as quick as possible and I wanted to do something more grounded emotionally," Webb told The Hollywood Reporter. "I wanted the actors to behave in a way that was more natural and that felt realistic and not stylised.
"And it's tricky to use the word 'grounded' when you have a nine-foot lizard running around the streets of New York, but we had a real person there interacting with Andrew to create some gravity and reality. So there was a philosophy that went beyond just the acting and the emotions, and that was keeping a level of physical reality and emotional reality."
He also explained his approach to action sequences.
"There's a learning curve with the action, I guess, but I tried to think of action as a sequence of scenes where the character was a little bit different at the beginning of the scene than at the end of the scene, and it's a way to create some emotional epiphanies," Webb continued.
"Like for example, the bridge scene is really a moment when Peter's motivation changes. At the beginning of the scene, he is motivated by vengeance and he's trying to satisfy some darker part of his soul... and at the end of the scene, he realises that he's got bigger shoes to fill, and he's got a more profound destiny."
The Andrew Garfield and Emma Stone-starring Amazing Spider-Man broke Tuesday box office records when it debuted earlier this week.
Watch a trailer for The Amazing Spider-Man below:
Photo gallery - 'The Amazing Spider-Man' London premiere: