Christopher Nolan's third and final Batman film is estimated to have made over $160 million (£102.9 million) at the US box office since its opening on Friday (July 20), according to The Hollywood Reporter.
This figure constitutes the biggest opening ever for a 2D film, outstripping movies including previous franchise instalment The Dark Knight, which made just over $158 million in its opening weekend.
Final box office numbers are being held back slightly, in a show of respect for the victims of Friday's massacre in Denver, Colorado.
The Avengers, which was released earlier this year in 3D, made over $207 million in its opening weekend.
> 'The Dark Knight Rises' on track for $150 million opening weekend
> 'The Dark Knight Rises': Digital Spy video review
> 'Dark Knight Rises' premiere interviews: Tom Hardy, Anne Hathaway, more
Watch Digital Spy's interview with The Dark Knight Rises director Christopher Nolan below: