Directed by longtime Entourage helmer Julian Farino, the comedy centres on the aftermath of an affair between a man (Laurie) and the daughter of a family friend (Meester).
Oliver Platt and Allison Janney play Meester's parents, while Alia Shawkat (Arrested Development), Catherine Keener and Adam Brody are also co-stars.
Laurie and Meester shared the screen previously in the third season of House, in which Meester guest-starred as a lovestruck patient.
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The Oranges will be released in the US on October 5, with a UK release date yet to be set. Watch the trailer below: