The film, written by Sylvester Stallone, stars James Franco and Jason Statham as a ruthless drug dealer and a former DEA agent who go head to head in a small town.
Based on a novel by Chuck Logan, the movie will be directed by Runaway Jury helmer Gary Fleder.
Ryder is currently in negotiations to play Franco's love interest, according to The Hollywood Reporter.
Production on Homefront is scheduled to begin on September 24 in New Orleans.
Ryder recently wrapped filming on The Iceman. She will next be seen in Tim Burton's animated movie Frankenweenie.
Watch a trailer for Frankenweenie below: