Announced earlier this year, House the House is a competition to discover the UK's best young DJ talent.
"Last Night a DJ Saved My Life and the House The House competition is a very genius and accessible opportunity for DJs to showcase their talent," the hip-hop duo said.
The winner of the competition will play a DJ set in the House of Commons, the first time it has opened its doors to such an event.
Applications are open to anyone at Mixcloud, and the best entries will be selected to play at regional heats in front of a panel of judges, starting October 2012.
Judges will include established DJs, club promoters and music professionals, and the heats will take place in Glasgow, Belfast, Cardiff, Sheffield, Liverpool, Manchester, Newcastle, Bristol, Brighton, Leeds, Birmingham and London.
The contest is open to DJs from 16 to 25 years old, and aims to empower young people interested in dance music across the country.
House the House is backed by UK Music, Youth Music, Mixcloud, PRS, Business Fights Poverty, Ministry of Sound DJ Academy, Vestax, Funktion 1 and NAP energy drink, among others.