The rapper's collaboration with Ms D sold over 114,000 copies to land straight at the top of the chart.
Calvin Harris and Example's duet 'We'll Be Coming Back entered at number two, having also broken the 100,000 barrier.
The Harris remix of Florence + the Machine's 'Spectrum (Say My Name)' falls to three after three weeks at the top. Maroon 5's 'Payphone' and Stooshe's 'Black Heart' each fall two spots to complete the top five.
Karmin are non-movers at six with 'Brokenhearted', while Rudimental celebrate a tenth week inside the Top 10 with 'Feel the Love' at seven.
Chris Brown stays at eight with 'Don't Wake Me Up', with Conor Maynard's 'Vegas Girl' and Flo Rida's 'Whistle' both falling five spots to complete the Top 19.
Underworld's 'Caliban's Dream' - the theme to the lighting of the Olympics cauldron last week - enters at 12. The track features Two Door Cinema Club's Alex Trimble on vocals. It is their first Top 40 hit in nearly ten years.
Far East Movement and Cover Drive continue to climb the chart with 'Turn Up the Love' at 13. Angel also climbs a spot at 19 with 'Wonderful'.
Arctic Monkeys land at 21 with their cover of 'Come Together' by The Beatles, which they performed live during the Olympics Opening Ceremony.
Drumsound and Bassline Smith enter at 34 with 'Through the Night', while Frank Turner lands at 40 with 'I Still Believe', the track he performed as the support act at the Olympics opener on July 27.
Watch the video for Wiley's 'Heatwave' below:
Source: Official Charts Company
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