The rapper confessed that he has "encouraged" same-sex activities in the past and would like any couple, regardless of gender differences or not, to be happy.
"I'm cool. I would like people to actually be happy," 50 Cent told Funkmaster Flex's Hot 97 radio show. "Technically I don't see where it fits into any religion.
"The Bible that they would read to marry you, it doesn't have anything in it that says same-sex. If it does, then I would like someone to point out that interpretation."
He added: "I've encouraged same-sex activities. I've engaged in fetish areas a couple times. I'm for it. I'm wondering if I'm bad for promoting it when the president says it's fine."
50 Cent was admitted to hospital earlier this week after reportedly suffering from a stomach bug.
> 50 Cent sued for allegedly sampling song without permission
Watch the music video for 50 Cent's 'Shooting Guns' below: