Ed Helms has announced plans to boycott the restaurant Chick-fil-A in protest against its president's anti-gay politics.
Dan Cathy, who is head of the Los Angeles-based chain, recently admitted to Christian magazine Baptist Press that the company opposes gay marriage.
According to TMZ, the company donated almost $2m (£1.3 million) to religious organizations against gay marriage in 2010.
Helms recently posted a response to Cathy's stance on gay marriage via his Twitter, saying: "Chick-fil-A doesn't like gay people? So lame. Hate to think what they do to the gay chickens! Lost a loyal fan."
The Hangover star is amongst several celebrities who have spoken out against the restaurant, including Lindsay Lohan and Miley Cyrus.
It was recently announced that Helms is in talks to star in a reboot of National Lampoon's Vacation.
Watch Ed Helms and Bradley Cooper talking to Digital Spy about The Hangover II below: