The Blue Peter and BBC Olympics presenter tweeted on Wednesday afternoon (August 1) that she doesn't have the "thick skin" to handle negative comments directed at her.
Skelton wrote: "Turns out I don't have very thick skin after all so I am closing my twitter account. Enjoy the games. Signing off, skelts x"
It is currently unclear what sparked Skelton's tweet, but it is assumed that she has been sent a negative message from at least one follower.
Her Twitter account was deactivated late on Wednesday evening, although many of her followers encouraged her to stay online.
Writer Graham Linehan came out in support of Skelton by retweeting her message, adding: "Another one down. This is why we can't have nice things."
A teenager has been given a warning and released on bail after he sent offensive tweets to Olympic diver Tom Daley.
Skelton became engaged to rugby player Richie Myler back in March.
Watch Digital Spy discuss the Olympics with a variety of stars below: