The Australian soap is filming in the city - the second largest in the country - this week.
Set to air at some point later this year, River Boys Brax (Steve Peacocke) and Heath (Dan Ewing) will provide the focus of the special episodes.
Shot mostly in the inner city, famous locations include Flinders Street Station, Federation Square and the Yarra River.
Series producer Lucy Addario teased: "We are excited to bring Home and Away to Melbourne again. We have a great Melbourne story that needs to be told and we look forward to working with local cast and crew.
"Fans can expect to see what The River Boys get up to outside of Summer Bay and the lengths they will go to protect their family."
In its 25-year history, Home and Away's characters have hardly been seen outside Summer Bay, this being only the second time scenes have been filmed in Melbourne.