The Boyzone singer and actor, who portrays Ciaran McCarthy, was last seen in Weatherfield in November last year.
When asked by Loose Women's Jane McDonald whether he would return to the soap for a third stint, Duffy proclaimed: "I would, I love the show."
Explaining his exit, Duffy said: "It's just, my family are based in Dublin and when I did Coronation Street, I was commuting over and backwards every weekend and it was very difficult.
"I made a conscious decision in September to come home for a year because my son was doing his big exam and my daughter was moving from national school to secondary school. I just needed to be at home for a year."
Duffy's 12-year-old daughter Mia suffers with autism.
> Keith Duffy: 'Producers say I always have a job on Corrie'