The character has been at the centre of several explosive storylines since arriving in Weatherfield in 2000, including giving birth to a stillborn baby, falling victim to a rape attempt by Frank Foster (Andrew Lancel) and becoming a widow when her husband Liam (Rob-James Collier) was murdered in a hit and run.
"You could write a book about what's happened to Maria," The Sun quotes her as saying. "If that happened in real life, she'd have ended up in a mental home by now."
Maria could be set to find happiness with Jason Grimshaw (Ryan Thomas) after the pair kiss in upcoming episodes, but Ghadie said that filming the scene was more awkward than romantic.
"Ryan and I are such good mates," she explained. "We get on so well. So when Maria starts getting very friendly with Jason it feels weird kissing Ryan.
"It's like kissing my brother. You don't get nervous, you just laugh a lot as it does feel so strange."
Ghadie claimed earlier this year that she enjoys Maria's sad plots as they are "the most fun for [her] to play".
The actress signed a deal in May to stay on Coronation Street until 2013.