Originally hosted by Cilla Black, the show famously created tearful surprises and family reunions for guests and the new special promises to "make some dreams of a lifetime come true".
"What an incredible honour to be asked to present this Surprise Surprise special for ITV1. I can't wait to get out there delivering new surprises to the nation," said Willoughby.
Exec Michael Kelpie added: "Surprise Surprise is one of those iconic ITV shows that I remember watching with my family growing up and the chance of bringing it back is a dream come true."
Producers are currently searching the country for people to appear in the series and want to hear from anyone who would like to nominate a member of the community for a "Willoughby surprise". Applicants should contact firstname.lastname@example.org.
The original LWT production of Surprise Surprise aired between 1984 and 1997 and famously featured host Black singing the theme tune at the start and end of every episode. The track featured on Black's Surprisingly Cilla album and was released as a single.
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Watch a clip of Cilla Black's 'Surprise Surprise' below: