During a paper review, the Sunrise presenter said that the statistics were "unbelievable", claiming that what some people considered bullying was merely "part of life".
Speaking about the report in the i newspaper, Holmes said: "The i leads on figures from an Ofsted report: almost half of children are bullied at school, now that I find just unbelievable. One out of two children.
"What do they constitute as bullying? Someone sticking their tongue out at them? There's bulling, let's take that very seriously but to say that one out of two children is put upon at school. Maybe that's just life, maybe that's what it's called."
When his co-presenter Charlotte Hawkins questioned him about his comments, he accused her of being "wimpy".
"If half the children feel they are being bullied whatever form that takes because for some people it might have to be quite severe for it to have an impact but for other people even taunts can make them feel like they are being bullied and that should count, in my opinion," said Hawkins.
Holmes replied: "Don't bully me. See, that's why the world is in the state that it is, people like you just being wimpy about everything.
"One in two children are bullied at school. Don't believe it, it's called growing up basically."
When criticised on Twitter by one individual for his remarks, Holmes replied: "Your opinion is that every second child is being bullied? Get a grip man, you are doing the fight against real bullying no favours."