Simon Cowell's ITV1 reality show, which launched the careers of Diversity, Susan Boyle and Spelbound, is on the hunt for acts with anything they consider a special talent.
Singers, dancers, comics, jugglers, magicians and stunt acts are all welcome to apply. The 2011 winner was Scottish singer Jai McDowall, who scooped £100,000 and a spot on the Royal Variety Show later this year.
Applicants wanting more details should go to www.itv.com/talent.
A source told Digital Spy: "The eyes of the world will be on Great Britain in 2012 and Britain's Got Talent wants to showcase what the country has to offer.
"As always, the show wants acts - no matter how unusual - to take on the judges and the dreaded buzzers for the chance to win a life-changing prize."
Ant & Dec will be back to host the show for the sixth run and Amanda Holden is expected to return as one of the three judges.
Michael McIntyre confirmed earlier this week that he will not be returning for a second series on the judging panel. David Hasselhoff is also rumoured to be leaving the programme.
> Paul O'Grady should judge 'Britain's Got Talent', say Digital Spy readers