The Elstree compound will open its doors for bespoke events on eight dates starting from September 15, with guests given the opportunity to compete in tasks and talk directly to Big Brother in the Diary Room among other treats.
"We are very excited to announce the launch of this once in a lifetime experience," said Matt Curran, business development manager for event agency Chillisauce.
"Big Brother is the reality television sensation of our time and [we are] proud that we are able to offer this ultimate event space to our clients."
The Big Brother house can hold a maximum of 100 guests and groups of 50 or less have the opportunity to take part in organised team building sessions.
Details on how to book an event for the compound can be can be found at HireTheBigBrotherHouse.com.
The current series of Big Brother will come to an end next Monday (August 13) and be followed by the launch of Channel 5's third Celebrity edition two days later (August 15).