The At Your Inconvenience artist, who is dating one of the reality show's stars Millie Mackintosh, made a brief cameo in the latest series.
However, Green is quoted by the Daily Star as saying: "I actually find it quite weird but there are people whose job it is to manipulate other people's lives for the sake of a TV programme."
"They set up those situations - I am not going on it," the 28-year-old rapper added.
Green last month had a spat with Made in Chelsea's Victoria Baker-Harber after comments she made about Mackintosh.
Green and Mackintosh have been a couple since February this year.
Watch Professor Green in the video for 'Never Be a Right Time' below: