The series - formerly known as Notorious - stars Meagan Good as a detective who returns to her hometown to investigate the death of her childhood friend.
Hinkle will play the wife of the "smart and cold" Edward Bowers (Tate Donovan), according to Deadline.
The actress - who will be a regular cast member on Infamous - has previously appeared in episodes of Don't Trust the B---- in Apartment 23, Brothers & Sisters and Law & Order.
Casting is still ongoing for the role of womanising bad boy Julian Lawson. British actor Neil Jackson played the role in the pilot, but later departed the project.
Victor Garber (Alias), Katherine LaNasa (Big Love) and Laz Alonso (Breakout Kings) will also star in Infamous.
The series will debut at midseason, in early 2013, on NBC.
> Ella Rae Peck, Makenzie Leigh cast in NBC drama pilot Notorious
Watch a trailer for Infamous below: