The Glee actor is said to be under consideration by Fox bosses to join the singing competition's second season, reports TV Guide.
McHale has been associated with The X Factor USA in the past, having performed during a live results show with the Glee cast during the first season. He also hosted a behind-the-scenes featurette which aired during the series premiere.
He is the latest celebrity to be linked to the programme, following Khloe Kardashian, Stacy Keibler and Pussycat Dolls star Ashley Roberts.
X Factor boss Simon Cowell has previously said that the show will be hosted by a man and a woman.
Popstar and former X Factor UK contestant Olly Murs has said that he would host the American version of the show and insisted that Cowell should consider him for the job.
Watch a trailer for The X Factor USA below: