VH1 will honour celebrity supporters of charity in August in the hopes of inspiring young people to get more involved in social causes.
The New Girl cast follow in the footsteps of Jane Lynch in hosting this year's Do Something ceremony.
VH1 president Tom Calderone said of this year's hosts: "We're thrilled to once again present the Do Something Awards. And with New Girl being one of the hottest shows of the year, we think our hosts Jake, Max and Lamorne will set exactly the right tone... This awards show is truly like no other.
"We were so encouraged by the huge star power that came out to support us last year. Instead of a recycled newspaper suit, I am going to create one of recycled cans... it will be noisy, but cool!"
Justin Bieber, Lady GaGa, Will Ferrell and David Beckham were all honoured at the 2011 gala.
The 2012 Do Something Awards air Tuesday, August 21 on VH1 at 9/8c.
Watch Justin Bieber win a prize at the 2011 Do Something Awards below: