The actress will reprise her role as Martha Huber in the season finale of the ABC series on May 13, according to The Hollywood Reporter.
Mrs Huber was murdered by classic Housewives villain Paul Young (Mark Moses) part way through the first season.
The character has appeared twice since through flashbacks, most recently in the season seven premiere in September 2010.
It was previously announced that Dana Delany will return as Katherine Mayfair for the Desperate Housewives finale, while series creator Marc Cherry will also make a brief cameo.
He this week assured fans that the show will conclude in a "very satisfying way".
Desperate Housewives returns to ABC on April 29. UK viewers can catch new episodes Sundays at 10pm on E4.