As Meredith, Derek, Cristina, Mark, Lexie and Arizona hop on a flight to take them to a surgery in Boise, we suddenly saw the aftermath of a horrific plane crash, which suddenly felt like a strange Lost crossover.
Creator Shonda Rhimes has stated that the episode - titled 'Flight' - will be a heartbreaking affair, and has also confirmed that the episode will definitely feature a major character death.
Cast member Sarah Drew (April Kepner) has teased the episode is on par with the infamous shooter episode of season six, stating: "It will affect everyone, but it happens outside of the hospital.
"The people that are at the hospital don't know it's happened yet by the end of the episode - I'm one of the people who is back at the hospital. Everybody is left with an uncertain future."
One would think that the death would surely be one of the plane crash victims, but this has not been confirmed. So the likes of Alex, Dr Webber, Owen, Jackson, Miranda and April are not definitely safe.
With leading stars Ellen Pompeo, Patrick Dempsey and Sandra Oh all recently signing up for season nine appearances, they would be the most unlikely candidates, but with Shonda Rhimes and Grey's Anatomy, anything is possible.
Who do you think we will be sadly saying goodbye to after 'Flight'? Let us know by voting in our poll and leaving a comment to explain your answers.
Grey's Anatomy airs tonight (May 17) at 9/8c on ABC.