The actor has appeared as bumbling hunter Garth in two episodes of the CW drama, 2011's 'Season Seven, Time for a Wedding!' and 2012's 'Party On, Garth'.
"I'll go back to Supernatural in a couple of weeks," Qualls confirmed at the TCA press tour. "It's one of my favourite shows to moonlight on. Jared Padalecki (Sam) is a really good buddy of mine and also they wrote the part for me."
Qualls added that he had a "great time" on Supernatural, according to Pop Culture Zoo, calling the show's devoted fans "insane".
"I did [a convention] in Birmingham, England," he revealed. "And literally people would just line up and hug you and cry - they love it."
Ricky Worthy (the Alpha Vampire) has also hinted that he will return to Supernatural next season.
Liane Balaban (Alphas) and Ty Olsson (Twilight) have also signed up for recurring roles.
The series returns to The CW in the US on October 3. In the UK, season seven of Supernatural begins airing Wednesday, August 1 on Sky Living.